Journal of Carcinogenesis & Mutagenesis

Alf Giese

Publications

• Review Article
  Perspectives and Challenges in Molecular-Based Diagnostics and Personalized Treatment for Recurrent High-Grade Gliomas
  Author(s): Darius Kalasauskas, Mirjam Renovanz, Sven Bikar, Anton Buzdin, Ather Enam, Sven Kantelhardt, Alf Giese and Ella L KimDarius Kalasauskas, Mirjam Renovanz, Sven Bikar, Anton Buzdin, Ather Enam, Sven Kantelhardt, Alf Giese and Ella L Kim
  
  Glioblastoma is the most common and most malignant type of intrinsic brain tumor in adults. The standard of care for glioblastoma consists of surgical debulking followed by combined radiochemotherapy. The clinical efficacy of standard therapies for newly diagnosed glioblastomas is rather modest with the highest survival rate at 5-years being less than 10%. Inevitable recurrence after cytotoxic therapies poses the major challenge in the clinical management of high grade gliomas. For recurrent glioblastomas, there is no standard therapy with lack of level one evidence for treatment efficacy. Recent evidence indicates that post-therapy recurrence in gliomas is a consequence of a plethora of molecular and cellular factors including intratumoural heterogeneity, functional hierarchy of distinct types of glioma cells, dynamic changes in the molecular landscapes and cellular composition of th.. View More»
  DOI: 10.4172/2157-2518.1000290

  Abstract PDF