Journal of Carcinogenesis & Mutagenesis

Afonin G

Publications

• Research Article
  G39179T DNMT3B Gene Variants in Relation to Colorectal Cancer Risk in Kazakhstan Population
  Author(s): Perfilyeva A, Abdikerim S, Zhunussova G, Iksan O, Skvortsova L, Khussainova E, Afonin G, Kaidarova D, Beckmanov B and Djansugurova LPerfilyeva A, Abdikerim S, Zhunussova G, Iksan O, Skvortsova L, Khussainova E, Afonin G, Kaidarova D, Beckmanov B and Djansugurova L
  
  Objective: Molecular-genetic study of the association between G39179T DNMT3B polymorphism and risk of the colorectal cancer in Kazakhstan population. Methods: The method of site-specific PCR amplification with following restriction of amplified fragments was used for the genotyping of G39179T DNMT3B polymorphism. Results: The DNMT3B 39179 GG genotype was associated with an increased risk of colorectal cancer development (OR=1.91, 95% CI=1.13-3.25, p=0.05). Separate analysis of population sub-groups showed that the GG genotype (vs GT+TT genotypes) was associated with a significantly increased risk of colorectal cancer among Russian (OR=2.10, 95% CI=1.07-4.10 p=0.03), individuals older than 60 years (OR=3.13, 95% CI=1.59-6.17 p=0.0008) and men (OR=3.96, 95% CI=1.52-10.31 p=0.004). Conclusion: We suggested that the DNMT3B G39179T polymorphism participates in modulation of susceptibility .. View More»
  DOI: 10.4172/2157-2518.1000242

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