Adriano CardozoFranciosi
Brazil
Research Article
Hemopressin an Inverse Agonist of Cb1 Cannabinoid Receptors Reverses Mechanical Sensitivity on Diabetes-Induced Neuropathy in Mice
Author(s): Elaine FlamiaToniolo, Adriano CardozoFranciosi and Camila SquarzoniDaleElaine FlamiaToniolo, Adriano CardozoFranciosi and Camila SquarzoniDale
Peripheral neuropathy is one of the most common complications of diabetes affecting about 50% of patients with the disease. The most prominent symptoms involve the extremities and occur as both an exaggerated response to noxious stimuli (hyperalgesia), mild or non-painful stimuli (allodynia). Hemopressin (Hp) is a non apeptide first found in rat brain extracts, which selectively binds CB1 cannabinoid receptors (CB1R) and exerts antinociceptive actions in experimental inflammatory and neuropathic pain models. However there is no data about its efficacy in neuropathic metabolic-related disease, like diabetes mellitus. The aim of this study was to investigate the role of Hp on mechanical and thermal sensitivity of mice submitted to an experimental model of type 1 diabetes mellitus-induced neuropathy. Mechanical allodynia and thermal sens.. View More»
