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The study was designed to investigate whether ultrasound-mediated microbubble destruction can enhance the transplantation of bone marrow mesenchymal stem cells (BMSCs) for myocardial infarction therapy, twenty myocardial infarction pigs were assigned into the ultrasound microbubble destruction group (n=12, Sonovue were infused into coronary artery with ultrasonic radiation, then BMSCs were injected into infarction region) and the cell control group (n=8, only subjected to BMSCs treatment). The increase of left ventricular ejection fraction was larger in the ultrasound microbubble destruction group (P<0.01), and more Prussian blue-positive cells and higher density of heart muscle capillary in the peripheral infarct regions were found (P<0.01). Prussian blue-positive cells were differentiated into new vascular endothelial cells in two cases, among which the gaps were widened in the microbubble destruction group. Our study first time testifies in pig models that ultrasound-mediated microbubble destruction promotes BMSC transplantation for myocardial infarction therapy.