Gynecology & Obstetrics
Open Access

Abstract

Treatment of Refractory Endometriosis-Related Pain with Vaginal Gestrinone in Pentravan Associated with Pinus Pinaster Extract and Resveratrol: A Preliminary Study

Hugo Maia Jr, Clarice Haddad, Maria Cristina de Moura Hirsch, Wilson S D dos Santos Junior and Julio Casoy

Introduction: Sexual dysfunction is common in patients with endometriosis and in the majority of cases the cause of sexual dysfunction is pain. The aim of this study was to investigate the effect of a combination of vaginal gestrinone with oral pinus pinaster extract and resveratrol on the pain scores of patients with deep endometriosis refractory to previous hormone treatment.

Methods: Fifteen patients were treated with a combination of 5 mg of vaginal gestrinone in Pentravan® (Fagron, the Netherlands) three times a week and 100 mg of oral pinus pinaster extract (Fagron, the Netherlands) together with 30 mg of resveratrol (Fagron, the Netherlands) daily.

Results: Mean pain score was 9 prior to treatment, reducing significantly to 3 (p=0.03) and 0.5 (p=0.004) after 1 and 2 months of treatment, respectively. After six months, all patients were pain-free. Amenorrhea rates were 80% after the first month, reaching 100% during the remainder of the treatment. There were no statistically significant changes in blood chemistry except for SHBG levels, which decreased significantly.

Conclusion: This preliminary observational study showed that the combined treatment of vaginal gestrinone with natural antioxidants is very effective for the treatment of refractory pain in patients with deep endometriosis.