Drug Designing: Open Access
Open Access

Abstract

Translational Pharmacophore Modeling: Bridging Bench-to-Bedside in Rational Drug Design

Keisuke Tanaka*

Translational pharmacophore modeling has emerged as a vital tool in the rational drug design process, offering a crucial bridge between early-stage molecular discovery and clinical application. A pharmacophore represents the abstract spatial arrangement of features in a molecule essential for its biological activity-such as hydrogen bond acceptors, hydrogen bond donors, aromatic rings and hydrophobic centers. By identifying and modeling these critical elements, scientists can create a blueprint for drug- receptor interactions that supports the screening, optimization and development of therapeutic agents. Translational pharmacophore modeling goes beyond traditional in silico screening; it incorporates experimental data, clinical observations and biological complexity to refine pharmacophores that are both predictive and functionally relevant in real-world disease contexts.

Published Date: 2025-03-04; Received Date: 2025-02-03