Journal of Alcoholism & Drug Dependence
Open Access

Abstract

The Role of Gut Microbiota in the Development of Alcoholic Liver Disease

Wei-Lin Huang*

Alcoholic Liver Disease (ALD) represents a major global health burden, accounting for a significant proportion of liver-related morbidity and mortality. While chronic alcohol consumption has long been recognized as the primary etiological factor, recent research has uncovered the critical involvement of the gut-liver axis in the pathogenesis of Alcoholic Liver Disease (ALD). Central to this axis is the gut microbiota a complex community of microorganisms residing in the intestinal tract that interacts dynamically with host metabolic, immune, and barrier functions. This article reviews the emerging role of gut microbiota in the onset and progression of alcoholic liver disease, emphasizing microbial dysbiosis, increased intestinal permeability, endotoxemia, and inflammatory signaling pathways as key mediators in the gut-liver crosstalk.

Published Date: 2025-03-04; Received Date: 2025-02-03