Gynecology & Obstetrics
Open Access

Abstract

Henri Essome, Vincent Ebenezer Ngambi , Fulbert Mangala Nkwele ,Jean-Yves Balepna ,Robert Tchounzou , Monique Audrey Ndamb, Moustapha Bilkissou, Astrid Ndolo Kondo; Ingrid Doriane Ofakem Ilick; Junie Ngaha Yaneu, Marga Vanina Ngono Akam; Gervais Mounchikpou Ngouhouo, Grâce Tocki Toutou; Ekono Michel Roger ; Charlotte Tchente Nguefack ,THeophille Nana Njamen

The onset of pregnancy is accompanied by multifaceted changes in women, including an anatomical and functional impact of the kidneys. Research question: is it possible to determine threshold values of renal function in our black pregnant women that can serve as reference data in our context? Objective: Our study aimed to determine the renal profile of pregnant women, to assess its evolution during pregnancy and to establish threshold values for basic metabolites. Methods: We conducted a prospective cross-sectional analytical study at Laquintinie Hospital in Douala from January 2022 to March 2022. Our study compared two groups of women, one of which (exposed) was made up of pregnant women and had recently given birth and another (unexposed or control) consisted of non-pregnant women. Our sampling was consecutive and not exhaustive. All our participants consented after been informed and the data were collected using a structured and pre-tested technical sheet. The study variables were sociodemographic, gestational, and biochemical. A bivariate analysis was performed with the ANOVA test as well as a Tukey post hoc analysis and a P value < 0.05 was the reliability threshold. Results: Out of 349 consenting women, we selected 200 eligible participants (100 pregnant and postpartum women, 100 controls). Relative to the control group, there were statistically significant differences in pregnant and postpartum participants regarding serum creatinine (8.7 vs 7.6 mg/l; P < 0.001), urea (21. 7 vs 15.1 mg/dl; P < 0.001), uric acid (48 vs 43.3 mg/l; P=0.034), sodium (137 vs 136 mmol/l; P = 0.002) and potassium (3.6 vs. 3.5 mmol/l; P < 0.001). We considered as threshold or reference the following values: 7.5 ± 1.1 mg/L throughout pregnancy for creatinine; 17.7 ± 4.7 mg/dl in the first trimester and postpartum, 14 ± 4.7 mg/dl in the second and third trimesters for urea; 35.5 ± 14.7 mg/l in the first two trimesters for uric acid; 135.6 ± 2.1 mmol/l for sodium throughout pregnancy; 3.5 ± 0.2 mmol/l for potassium during gestation. Conclusion: Our study, in the light of the already known, confirms, with a few nuances (chloride), a decrease in the basic metabolites of the renal function of the pregnant woman and initiates an outline of the reference values of the basic metabolites in our context

Published Date: 2023-12-25; Received Date: 2023-08-28