Biochemistry & Pharmacology: Open Access
Open Access

Abstract

The protective effect of piperine against isoproterenol induced inflammation in experimental models of myocardial toxicity

Vijaya Padma Viswanadha

Myocardial infarction (MI) eventually exacerbates inflammatory response due to the release of inflammatory and pro-inflammatory factors. The aim of this study is to explore the protective efficacy of piperine supplementation against the inflammatory response in isoproterenol (ISO)-induced MI. Masson Trichome staining was executed to determine myocardial tissue architecture. Immunohistochemistry was performed for IL-6, TNF-α. RT-PCR studies were performed to ascertain the gene expression of IL-6, TNF-α, iNOS, eNOS, MMP-2, MMP-9, and collagen-III. Western blotting was performed to determine expression of HIF-1α, VEGF, Nrf-2, NF-

Published Date: 2021-01-22; Received Date: 2020-12-15