Anatomy & Physiology: Current Research
Open Access

Abstract

The Physiology of Inflammation and Tissue Repair Mechanisms

Samuel Okoro

Inflammation and tissue repair are fundamental physiological processes that preserve the structural and functional integrity of the human body. Traditionally, inflammation has been viewed primarily as a defense mechanism against infection and injury. However, recent advances in molecular biology, immunology and regenerative medicine have revealed that inflammation is not merely a response to damage but also a tightly regulated process that initiates healing and restores tissue homeostasis. From this understanding the physiological interplay between inflammation and tissue repair is essential for developing innovative therapeutic strategies capable of promoting regeneration while minimizing chronic disease progression. The inflammatory response begins immediately following tissue injury or pathogen invasion. Resident immune cells, including macrophages, mast cells, and dendritic cells, recognize Danger Associated Molecular Patterns (DAMPs) and Pathogen Associated Molecular Patterns (PAMPs) through pattern recognition receptors.

Published Date: 2025-02-03; Received Date: 2025-01-03