Chemotherapy: Open Access
Open Access

Abstract

The Neurotoxic Effects of 2-Nitropropane on Nerve Conduction are Reversible, In Vitro

Sergio Lucio Becerra-Torres and Luis Castillo-Hernández

In general, the scientific evidence points to organic solvents as substances capable of affecting the nervous system, both central and peripheral level. The aim was to measure the effect of 2-nitropropane on the sciatic nerve of the frog in vitro . We found significant effects on parameters such as nerve conduction velocity, amplitude and duration of the compound action potential, and nerve impulse conduction. The importance of our results is that there was a reversible behavior simulating the effect of the anesthetics used in medical practice. Due to the depressive effect shown by this solvent we strongly recommend health surveillance of those who are in constant exposure to organic solvents and the use of personal protective equipment indicated in the corresponding safety sheets to manipulate these xenobiotics.