Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Rungprakai Injong, Nicha Somlaw, Thanapoom Rattananupong, Nattaya Teeyapun, Virote Sriuranpong, Suebpong Tanasanvimol, Napa Parinyanitikul*
Background: Malnutrition affects individual fitness popularity and influences the response to chemotherapy in cancer sufferers. Moreover, chemotherapy may additionally get worse the nutritional popularity in these sufferers and vice versa. Consequently, Oral Nutrition Dietary Supplements (ONS), either general or unique system, have been advocated via several tips in these settings. Immunonutrition formulas theoretically offer a higher anticachectic and anti-tumor effect to an ordinary weight loss plan or standard formulation. Our take a look at changed into aimed to evaluate the impact of ONS with immunonutrients and standard ONS on grade II-IV neutropenia in Gastrointestinal (GI) cancer that has received palliative chemotherapy.
Methods: We carried out a unmarried-center, double-blind, prospective controlled trial in sufferers with advanced GI cancer who acquired palliative chemotherapy. Patients were randomized into corporations, ONS with Immunonutrients (ONS-IM) and general ONS system (ONS-SF) with 500 kcal/day. The primary endpoint turned into the incidence of neutropenia grade II-IV. Furthermore, frame weight, frame composition, PG-SGA (affected person-generated subjective international assessment) scores, dietary consumption, anti-inflammatory parameters and remedy toxicities were evaluated at baseline and 12 weeks after chemotherapy between two corporations.
Results: A complete of 50 sufferers had been included (24 vs. 26 in the ONS-IM vs. the ONS-SF, respectively). All sufferers have been recognized with colorectal cancer, 24 (48%) had been men, with a mean age of 65.8 years (IQR 34-84). PG-SGA ≥ 9 was 60%, 46% had ≥ 2 organ metastases and 54% acquired first-line chemotherapy. There have been no statistical variations within the baseline traits among the two businesses. Neutropenia grade II-IV happened less frequently inside the ONS-IM group compared to the ONS-SF institution (16.7% vs. 42.3%, P=0.067), mainly in subgroup of patients who received both ONS-IM or ONS-SF greater than 70% (14.3% vs. 45.8%, P=0.028). The suggest variations within the PG-SGA rating were extensively higher inside the ONS-IM as compared to ONS-SF institution (6.7; 95% CI: 5.35, 8.14 vs. 4.72; 95% CI: 3.09, 6.35, P=0.05). Frame fat mass and the proportion of CD3 be counted had been improved extensively within the ONS-IM organization as compared to the ONS-SF organization. There was no difference in different anti-inflammatory markers among the 2 businesses.
Conclusion: Sufferers who had been supplemented with immunonutrition established a lower in grade II-IV neutropenia, stepped forward PG-SGA ratings, frame fats mass and the proportion of CD3 counts.
Published Date: 2025-04-21; Received Date: 2024-03-11