Driving is an important task that demands the full attention of the driver. There are many different factors that can compromise driving performance and lead to vehicle crashes. Perhaps two of the most common, yet also the most dangerous, are drug (including alcohol) influences on driving and distractions using handheld devices like cell phone calls and/or texting. Although each of these driving disruptors has been studied separately and has been shown to adversely affect driving performance, there is a paucity of data regarding the effects of these driving disruptors when combined. Given the explosion of handheld electronic devices, and the likelihood that drivers are using these devices when they are driving, it is not surprising that reports of crashes relating to this 'triple threat' combination of drugs (including alcohol), texting and driving are on the rise and in the news. Clearly, this 'triple threat' of texting, drugs and driving is a problem that requires research attention.