Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Targeting Inflammatory Biochemical Pathways for the Development of Anti-Inflammatory Pharmacological Agents

Mariana Lopez Cardenas*

Inflammation is a complex physiological response triggered by infection, injury, or immune dysregulation. While acute inflammation is protective and necessary for tissue repair and defense against pathogens, chronic inflammation underlies numerous pathologies including rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma and even metabolic and neurodegenerative disorders. The development of pharmacological agents that specifically target key inflammatory biochemical pathways offers a promising strategy for mitigating such conditions. The intricate network of cellular and molecular mediators involved in inflammation such as cytokines, chemokines, prostaglandins, leukotrienes and reactive oxygen species provides multiple potential targets for drug intervention. Understanding these pathways at the molecular level is essential for designing therapeutic agents that can selectively suppress pathological inflammation while preserving normal immune function.

Published Date: 2025-03-04; Received Date: 2025-02-03