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Wenlu Liu, Xizhen Jiang, Wei Zhang, Faqin Jiang and Lei Fu
Based on a benzofuran skeleton bearing aryl substituent at its C-3 position through an α, β-unsaturated ketone linker, twenty-one new compounds were chemically synthesized and biologically evaluated for their antibacterial activities against four bacteria, Escherichia coli, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, and Bacillus subtilis. Nine of the synthesized benzofuran derivatives exhibited antibacterial activities. Among them, compound 7e showed excellent MIC80 values from 0.78 to 1.56 μg/mL and was comparable to the positive control drugs.