Dental stem cells, a new area of stem cell research is gaining popularity due to its easy accessibility and plasticity. On other hand iPSc (induced pluripotent stem cells) which can be generated from many tissues in the body has attracted many researchers towards it. This brief communication comparatively reviews the advantages and disadvantages of Dental Stem Cell Banking (DSCB) with iPSc. Similar to cord cell banking DSCB can also serve as source for stem cells. Reprogramming the cells by transfecting with specific transcriptional factors helps in deriving the iPS cells. Recent studies have shown dental pulp cells can be efficiently reprogrammed than dermal fibroblasts in generating iPSc. Other than dental pulp, iPS cells were also made from other tissues of oro-dental region which includes gingival, buccal mucosa and periodontal ligament. The disadvantages of iPS cells like, tumor and teratoma formation can be avoided by newer non integration techniques. It can be concluded that though iPSc cannot replace DSCB in the present scenario but, in future it has paramount role in regeneration after prospective research.