Journal of Chemical Engineering & Process Technology
Open Access

Abstract

Successful Application of the Lipase as a Catalyst in the Combinative Approach, Using an Efficient and Selective Iterative Procedure for the Chemo-Enzymatic Alpha-Amino Group Protection in the Natural Amino Acids, Representing the Ornithyl Model System as a Starting Research Pattern: Homogeneous and Heterogeneous Synthesis

Bayryamov SG

The successful efficient combinative approach for iterative and selective chemo-enzymatic amino group protection was realized at mild conditions, using the lipase as a catalyst, without its regeneration and step isolation from the reaction mixture, which allows the elegant large-scale preparation of N-protected amino acids derivatives for the conventional peptide synthesis.