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Diabetes Mellitus is a modern epidemics and refractory disease caused by overeating or insulin-related pathogenesis. However, treatment for diabetes mellitus is no easy task. There are many problems facing diabetes mellitus therapy; Insulin or its peptide derivatives need needle injection every day, which lead to treatment inconvenience and burdens for patients; Disease complications, such as cardiovascular symptoms, eye impairment or kidney failure are even fatal for some of patients; Drug toxicities owing to long-term utilization of chemical drugs are equally harmful for patients. In this editorial, we will offer some new ideas for building diabetes mellitus treatment systems, drug design and development pipelines and possible future directions are given and highlighted.