Current Synthetic and Systems Biology
Open Access
ISSN: 2332-0737
ISSN: 2332-0737
Debra Kimless*, J. Phillip Kennedy, Janet Zand
Microplastics (MPs) are pervasive environmental contaminants with documented systemic distribution in mammals. Companion dogs share household MP exposure pathways with their owners and may serve as sentinel indicators of environmental burden. We report a preliminary, owner-initiated, single-arm observational case series in which five companion dogs from one household received a companion animal-specific, food-grade Plastic Adsorptive Compound (PAC) at 1 mg/kg body weight twice daily for 42 days. Blood was drawn at baseline and Day 42 and analyzed by an independent third-party laboratory using validated microscopy-based polymer identification. Cohort level circulating particle count fell from 71 to 23 (-68%) and estimated surface-area burden fell from 554,805 to 125,978 µm² (-77%); four of five dogs showed count reductions and all five showed surface-area reductions. No adverse effects were observed. Because this report used no control or placebo arm, no randomization, and a single pre/post measurement in one household, these findings cannot establish efficacy and are consistent with-but do not rule out-regression to the mean or unmeasured temporal confounds. We present these results as a preliminary pilot observation, and describe in a larger, crossover, multi-timepoint trial currently underway (n=40, over 180 days) to confirm whether the pattern reported here holds under controlled conditions.
Published Date: 2026-08-25; Received Date: 2026-07-24