Clinical & Experimental Cardiology
Open Access

Abstract

Red Rice DE 40 and its Potential in Alleviating Hyperlipidemia

Durairajan Sudha, Sundaresan Uma, Ganesan Ariharasivakumar*, Selvaraj Varalakshmi , Muthiah Chellapandian, Patrick A. Kalona

Hyperlipidemia, a condition marked by elevated plasma lipid levels, is a major risk factor for cardiovascular diseases, obesity, and metabolic syndromes. Conventional lipid-lowering therapies, such as statins, are effective but often carry side effects, necessitating safer, natural alternatives. Red Rice (RR) DE 40, a bioactive-rich extract, has demonstrated antihyperlipidemic effects in preclinical studies. This mini-review summarizes current evidence on RR DE 40's efficacy in reducing body weight, modulating lipid profiles, improving liver function, and correcting hematological disturbances in High-Fat Diet (HFD)-induced hyperlipidemic rats. RR DE 40 showed comparable results to rosuvastatin and exhibited no toxicity at high doses. These findings support further exploration of RR DE 40 as a potential natural alternative for managing hyperlipidemia and associated disorders.

Published Date: 2025-05-19; Received Date: 2025-04-16