Hafiza Sobia Ramzan, Hafiz Faizan Lateef and Qamar Zaman
Introduction: The malignant tumors of torment and life taking pancreatic cancer account for adeno-carcinoma which finds its origin in the exocrine secretions of pancreas. Though a lot many techniques and methodologies are surfacing in the field of medical science but still the overall survival rate is not remarkable. The recommended treatment for local tumor control is the implantation of the I125 radioactive seed (brachytherapy) in the effected organ.
Objective: This study was carried out in order to reveal the individual and synergistic efficacy of I125 and ING4 for the treatment of pancreatic cancer tumors. Both in vitro (pancreatic cell lines) and in vivo (in mouse model) investigations were performed.
Material and methods: The vibrant combination of ING4 and radiotherapy with I125 for treating pancreatic cancer had been done before this appraisal unknown. We investigated that whether ING4 and I125 radiotherapy treatment can suppress Panc-1 pancreatic cancer cell tumor growth or not using in vitro and in vivo substrates.
Results: In this study, we demonstrated that either ING4 or (125)I radiotherapy treatment could induce Panc-1 pancreatic cancer cell growth suppression and apoptosis in vitro. The outcomes revealed that both treatments inhibited can inhibit the malignancy of pancreatic cancer with their tumor suppressive functions. Hence (ING4) gene therapy plus (I125) radiotherapy had produced synergistic effects.