Legg-Calve-Perthes disease (LCPD) is a childhood disorder of the femoral head most commonly seen amongst boys of 4-8 years of age. It occurs due to inadequate blood supply to the femoral head. We report the case of 7 year 8 month old girl who presented with short stature and was started on growth hormone replacement therapy for growth hormone deficiency. After 2 years and 8 months on growth hormone she developed Legg Calve Perthes. She continued to follow up in endocrinology clinic and was continued on half of her required dose of growth hormone without any further complications. To our knowledge this is the first reported case of LCPD in pre-pubertal girl on Growth hormone (GH).