Gynecology & Obstetrics

Gynecology & Obstetrics
Open Access

ISSN: 2161-0932

+44 1704335730


Premenstrual Syndrome (PMS) Treatment with Physiological Modulators

Cornelli U, Hernandez Santos JR , Belcaro G

Background: Premenstrual syndrome (PMS) is a very common disease in females, and safe treatments are still needed. Objective: To treat symptoms of PMS using a combination of natural products at low dosages following the concepts of Physiological Modulation. Material and Methods: Twenty two female affect by PMS were admitted and treated with a combination consisting of calcium, Vitamin D, lycopene, astaxanthin , and citrus bioflavonoids (Formula A28) in comparing with placebo. Two tablets/day were given at the moment of symptoms appearance and for the following three days. The scoring of somatic and behavioral symptoms (in total 32) was applied using a scale between 0 (no symptom) to 4 (maximum expression of the symptom). The main variable to be measured was the sum of the scores (total score). Results: Formula A28 was effective in reducing by 75 % the total score (t test p<0.05) and each of the symptoms (somatic and behavioral) was significantly reduced (p<0.05 U Mann Whitney test) from the 63 % (anxiety) up to 96 % (indecision). Colic pain was also consistently reduced (83 %). Conclusions: The approach to reduce symptoms of PM Susing Physiological Modulators was found to be effective. Keywords: Premenstrual syndrome; Physiological modulation; Somatic symptoms; Behavioral symptoms.

Published Date: 2020-04-09; Received Date: 2020-03-25