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PolyPRep: A Simple Tool for Fragmentation and Modelling 3D Structures of the Unresolved Polyproteins. | Abstract
International Journal of Biomedical Data Mining

International Journal of Biomedical Data Mining
Open Access

ISSN: 2090-4924

Abstract

PolyPRep: A Simple Tool for Fragmentation and Modelling 3D Structures of the Unresolved Polyproteins.

Fernando Limoeiro, Maria Fernanda Ribeiro Dias, Vinicius Santos de Pontes and Manuela Leal da Silva

In recent years, the development of high-throughput technologies for obtaining sequence data leveraged the possibility of analysis of protein data in silico. However, when it comes to viral polyprotein interaction studies, there is a gap in the representation of those proteins, given their size and length. To prepare for studies using state-of-the-art techniques, such as Machine Learning, a good representation of such proteins is a must. We present an alternative to this problem, implementing a fragmentation and modeling protocol to prepare those polyproteins in the form of peptide fragments. Such procedure is made by several scripts, implemented together on the workflow we call PolyPRep.

Published Date: 2021-09-10;