Journal of Clinical Toxicology
Open Access

Abstract

Plasma Exchange as an Effective Treatment for Severe Copper Sulphate Poisoning: A Review of Copper Sulphate and Zinc Phosphide Poisoning

Manannalage Dinusha Gayathri*, Hettiarachchi Nirosha Madhuwanthi

Copper sulphate and zinc phosphide poisoning can have profound fatal effects on multiple organ systems and present significant challenges in clinical management. We report a case of a 24-year-old female who developed methaemoglobinemia following acute poisoning from copper sulphate and zinc phosphide. In spite of initial treatment with methylene blue, vitamin C and Dpenicillamine, the patient continued to experience haemolysis. Based on the available evidence, plasma exchange therapy was administered to address the persistent haemolysis. Significant improvement in haemolytic parameters were seen post treatment, showing a positive response to plasma exchange. The case presented here underscores the importance of a multidisciplinary approach in managing complex poisonings and highlights the potential effectiveness of plasma exchange as an adjuvant therapy for treating haemolysis caused by severe copper sulphate poisoning. To the best of our knowledge, this is the first documented case of combine copper sulfate and zinc phosphide poisoning worldwide.

Published Date: 2025-06-09; Received Date: 2024-05-28