Journal of Developing Drugs
Open Access

Abstract

Pharmacokinetics and Bioavailability of a Liposomal Formulation of Curcumin in Preclinical Models

Soren Mikkelsen*

Curcumin, the principal curcuminoid extracted from Curcuma longa, has demonstrated extensive pharmacological potential, including anti-inflammatory, antioxidant and anticancer activities. Despite these promising properties, its clinical application remains limited due to extremely poor oral bioavailability, rapid metabolism and low systemic circulation following administration. To overcome these limitations, advanced drug delivery systems such as liposomal encapsulation have been proposed. In this study, a novel liposomal formulation of curcumin was developed and evaluated for its pharmacokinetic behavior and oral bioavailability in preclinical animal models. The primary objective was to enhance curcumin’s solubility, stability and systemic absorption through nanocarrier-based delivery.

Published Date: 2025-03-04; Received Date: 2025-02-03