Anatomy & Physiology: Current Research
Open Access

Abstract

Organ-on-a-Chip Technologies for Studying Human Physiology

Yara Haddad

Organ on a Chip (OoC) technology has emerged as one of the most transformative innovations in biomedical research, offering unprecedented opportunities to investigate human physiology under controlled laboratory conditions. By integrating microengineering, cell biology, biomaterials and microfluidics, these miniature devices recreate key structural and functional characteristics of human organs. Unlike conventional two dimensional cell cultures or many animal models, organ on a chip platforms provide dynamic physiological environments that more closely mimic human tissue architecture, mechanical forces and biochemical signaling. As a result, they are rapidly becoming valuable tools for studying normal physiology, disease mechanisms, drug development and precision medicine. Traditional experimental models have significantly advanced physiological research, yet each has important limitations.

Published Date: 2025-06-02; Received Date: 2025-05-02