Endocrinology & Metabolic Syndrome

Endocrinology & Metabolic Syndrome
Open Access

ISSN: 2161-1017


Obesity, Non Alcoholic Fatty Liver Disease (NAFLD) and Coronary Artery Disease (CAD)

Dhastagir S. Sheriff and Manopriya T

NAFLD is recognized as risk factor per se for Coronary Artery Disease (CAD). Subjects with fatty liver have an increased risk to develop CAD, and are accompanied by an increase in inflammatory markers, C-reactive protein and also proatherogenic factors. Studies evaluating endothelial function showed that subjects with Non alcoholic fatty liver disease (NAFLD) had decreased endothelium-dependent vasodilatation correlated with the severity of liver disease In these subjects a strong association was seen with high triglycerides, suggesting that hypertriglyceridemia might be a crucial link between hepatic steatosis, insulin resistance, and endothelial dysfunction.