Journal of Developing Drugs
Open Access

Abstract

Novel Anticancer Agents: Design, Synthesis, and In Vitro Evaluation of Quinoline-Based Hybrids

Andreas Meier*

The pursuit of more effective and selective anticancer agents continues to be a high priority in drug development, particularly in the context of chemoresistance and non-specific cytotoxicity associated with current therapies. Quinoline-based compounds have shown promising anticancer potential due to their versatile structure and ability to interact with key biological targets such as DNA, topoisomerases, and kinases. In this study, a series of novel quinoline-based hybrid molecules were designed and synthesized with the objective of enhancing anticancer efficacy while minimizing off-target effects. The hybrids were structurally modified by introducing various pharmacophores such as aryl sulfonamides, thiosemicarbazones, and azoles at the positions of the quinoline nucleus. 

Published Date: 2025-04-03; Received Date: 2025-02-03