Yeoheung Yun, Laura Conforti, Perpetua Muganda and Jagannathan Sankar
Understanding the disease mechanisms of complex biological systems is still a significant challenge. Biological systems consist of hundreds of thousands of genes and proteins which are very hard to identify and whose behavior is difficult to correlate, understand and predict. The traditional hypothesis-driven basic research aims to study a certain gene/protein or a certain signalling pathway by taking a biological system apart in such a way that is strictly dependent on the scientific method applied. However, this approach cannot provide a systemic information broad enough to predict the complex dynamic consequences of altered gene and protein expression and, ultimately, drug effectiveness. Synthetic biology, in combination to classical methods, is recently emerging as an alternative method.