Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Nanocarrier-Based Drug Delivery Systems: A Biochemical Perspective

Haruka Aoyama*

Nanocarrier-based drug delivery systems have emerged as transformative platforms in modern pharmaceutical sciences, offering highly targeted, efficient, and controlled therapeutic delivery. Over the past two decades, these nanoscale vehicles ranging from liposomes, dendrimers, polymeric nanoparticles, to micelles and solid lipid nanoparticles have reshaped the approach to treating diseases, especially those involving complex biochemical environments such as cancer, neurodegenerative disorders, and infectious diseases. The principle driving nanocarrier technology is the ability to exploit physicochemical and biochemical interactions at the nanoscale, facilitating improved bioavailability, reduced systemic toxicity, and enhanced therapeutic index of loaded drugs. These systems are engineered to carry drugs through physiological barriers while preserving the therapeutic agent's integrity and releasing it in a controlled manner at the intended site of action.

Published Date: 2025-03-04; Received Date: 2025-02-03