Journal of Nanomedicine & Biotherapeutic Discovery
Open Access

Abstract

Nano Pharmaceutical 2019: Synthesis of porphyrins bearing trans-thiols: A good perspective in nanotechnology- Raymond C Jagessar- University of Guyana, Guyana

Raymond C Jagessar

There are several interesting reports on the electrical properties of meso-substituted porphyrins. Meso-substituted porphyrins electrical properties can be modulated through various meso-substituted patterns and the use of the type of metal in porphyrin metal complexation. This class of compounds has yielded interesting results in the nanopore arena or embodiment. Thus, their availability via high yielding synthesis is necessary. Hence, a route to porphyrins bearing trans-thiols is described in this lecture. The synthesis involves a thioacetyl containing aldehyde or a thioacetyl containing dipyrromethane in the presence of catalytic BF3.OEt2 followed by oxidation. Metal complexation and ammonium hydroxide induced acetyl removal to provide a route to these important molecular systems for future electronics experiments in which the thiols would serve as the adhesion points to gold probes.

 

Published Date: 2021-02-11; Received Date: 2021-01-06