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Leela S Pillarisetty, Meridyth Buschardt and Maneesh Mannem
Background: Breast cancer diagnosis and treatment during pregnancy is relatively rare, and breast sarcomas constitute a small, aggressive subset of breast malignancies. This paper describes a novel case of metastatic breast sarcoma diagnosed and treated during pregnancy. Surgery, chemotherapy, and radiation given at the right time remain a cornerstone of breast cancer treatment during pregnancy. Current evidence suggests minimal treatment effects on immediate and longer-term fetal outcomes. Maternal outcomes are also significantly improved with prompt diagnosis and treatment.
Case Report: This report describes the case of a 24-year-old female diagnosed with breast sarcoma metastasizing to the lungs, liver and the brain in pregnancy. She was 33 weeks of gestation at the time of diagnosis and had bilateral lung and liver metastasis at the time of presentation. Labor was induced at 34 weeks gestation. She had a spontaneous vaginal delivery without complications, and the infant weighed 5.07 pounds with an Apgar score of 8 and 9. Immediate treatment with Doxorubicin and Ifosfamide (Mesna was also given) was initiated after delivery. Her postpartum course was complicated by a collapsed lung, MRI did later reveal metastasis to the brain as well. Palliative chemotherapy was ultimately pursued.
Conclusion: This paper describes a novel case of metastatic breast sarcoma diagnosed during pregnancy, and reviews the current literature regarding sarcomas and breast cancer treatment in pregnancy. Sarcoma is a rare type of breast cancer, and presentation in this age group is very unusual. To the best of our knowledge, this is the first case report on breast sarcoma in pregnancy.
Published Date: 2019-05-21; Received Date: 2019-04-23