Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Metabolomic Analysis of Hepatotoxic Responses Induced by Commonly Prescribed Pharmaceuticals

Lin Chia-Yun *

The liver is the principal organ responsible for drug metabolism and detoxification, making it particularly susceptible to injury caused by xenobiotics, including pharmaceuticals. Drug-induced liver injury remains a major clinical challenge and a leading cause of acute liver failure, often necessitating drug withdrawal or dosage adjustments. The complexity of hepatic responses to pharmaceuticals has prompted a shift toward advanced investigative tools such as metabolomics a high-throughput, comprehensive approach that captures global metabolic perturbations within biological systems. Metabolomic analysis, especially using mass spectrometry and nuclear magnetic resonance based platforms, enables detailed profiling of small- molecule metabolites, offering valuable insights into drug- induced hepatic stress, energy metabolism disruption, oxidative damage and other pathophysiological processes.

Published Date: 2025-03-04; Received Date: 2025-02-03