Medical & Surgical Urology
Open Access

Abstract

Mature and Immature Teratoma: A Review of Pathological Characteristics and Treatment Options

David Wetherell, Mahesha Weerakoon, David Williams, Bhawanie Koonj Beharry, Ania Sliwinski, Darren Ow, Kiran Manya, Damien M Bolton and Nathan Lawrentschuk

Testicular teratoma is a sub-type of Non-Seminomatous Germ Cell Tumour (NSGCT) and often occurs in two distinct age groups. Adult testicular teratomas are often mixed and are malignant. Teratoma can be divided histologically into mature and immature. Pure mature teratoma of the testis is rare. Intratubular Germ Cell Neoplasia (ITGCN) is a common feature associated with teratoma. Teratoma is frequently chemoresistant and clinical management of these tumours includes radical inguinal orchidectomy followed by Retroperitoneal Lymph Node (RPLND) dissection if indicated. Long-term oncological outcomes for mature and immature testicular teratoma are equivocal.