Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Inflammation and Brain: Regulation of Systemic Inflammation in Sepsis

Yukio Imamura, Nao Yoshikawa, Yuki Murakami, Satoko Mitani and Akitoshi Seiyama

Inflammation is a biological response to harmful stimuli with pathogens or chemical irritants, etc. The inflammation serves as a chemical sign of the wound healing. Various biochemical substances
enroll the processes. For example, cytokines (e.g. interleukins) secreted from immune cells such as macrophage, T cell or B cell induce an acute inflammation, trigger the proliferation and/or differentiation of other immune cells and regulate the chemo-attractant migration of immune cells. These acute inflammatory responses are usually ceased when the stimulant is removed and the biochemical reactions are useful to maintain the living organisms.