Journal of Glycobiology

Journal of Glycobiology
Open Access

ISSN: 2168-958X

+12 184512974


Immune Response Modulation by Tumor-Secreted Glycosphingolipids

Ricardo D Lardone, Ingrid Cely, Peter A Sieling and Delphine J Lee

Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) are now recognized as having critical effects on cellular physiology, including proliferation, differentiation, viral transformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL composition compared to parental normal cells. These modifications may contribute to both tumor survival and exert striking effects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.