Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X


Imaging Mass Spectrometry and Its Methodological Application to Murine Tissue

J.O.R. Gustafsson, S. R. McColl and P. Hoffmann

Imaging mass spectrometry (IMS) is an emerging technology, pioneered by Prof. Richard Caprioli’s group starting more than a decade ago. In this study we have demonstrated the simplicity of initial technological set up for IMS experiments with commercially available automated matrix deposition, MALDI-TOF mass spectrometry instrumentation and data handling software for image generation. We have applied two different concepts of automated matrix deposition on Murine brain sections and discussed their different features and capabilities in IMS.