One of the actual threats to the nation’s and human security is the alarming rate of illicit drug trafficking (IDT). The menace of illicit drug trafficking poses heinous threats to human lives, national development and security. Most of the Nigerian borders are porous, therefore, giving room for easy influx, movement and exit of drugs. However, the failing economy, insecurity, high rate of graduate unemployment, poverty, failure of government to provide basic necessities of life, high level of corruption and get-rich-quickly syndrome among the youths in Nigeria, constitute the various banes behind the practice of illicit drug trafficking in the state. This study interrogates the obstacles and threats posed by drug trafficking to human lives, state’s development and national security; it assesses the concerted efforts of the Nigerian government aimed at combating the menace with a plan to proffer solutions on how to checkmate the disheartening phenomenon. The study concludes that, lack of adequate intelligence gathering, insecurity, bribery and corruption, poverty, civilization and porous borders stand as a cog in the wheel to appreciable efforts at arresting the menace in the country. It also submits that there is need for sound orientation/education, strong law and good governance, adequate intelligence gathering to solve the problem in addition to the imperative role of law enforcement agencies for sustenance of a drug-free society and state.