Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Alejandra Torres Ruiz*
Alcohol dependence is a complex and multifactorial disorder influenced by a combination of genetic predispositions, environmental exposures, and neurobiological changes. In recent years, the field of addiction genetics has shifted from a purely genetic model to a more integrative view that includes epigenetic mechanisms heritable changes in gene expression that occur without altering the DNA sequence. This systematic analysis reviews the current understanding of both genetic and epigenetic markers associated with alcohol dependence, highlighting the interplay between inherited vulnerabilities and environmental triggers such as early-life stress, trauma, and chronic alcohol exposure.
Published Date: 2025-03-04; Received Date: 2025-02-03