Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Female Infertility (AMH and FSH) over the Age of 35 in the Dukagjini Region in the Republic of Kosovo

Afrim Zeqiraj, Zafer Gashi, Sanije Berisha, Sadi Bexheti, Shkelzen Elezaj and Agim Shabani

Background: Female infertility is a complex clinical condition affecting both sexes women and men and has a significant influence on their mental status, lifestyle and relationships between them. For all married couples around the world, the desire to give birth to a healthy child is emphasized and this information is also indicated in the United Nations Declaration on Human Rights, Article 16.1, which states that "men and women without any restriction on race, nationality or belief, have the right to marry and build a family".
Purpose of work: It is to determine the degree of female infertility of women over the age of 35. Work has been done in the Dukagjini Region in Peja, in the Republic of Kosovo.
Materials and methods: Sampling was conducted over a period of time from January 2014 until June 2017, a total of 189 samples, 139 samples for analysis and 50 samples for checks were collected. Measurement of hormone parameters was done with Roche Elecsys's 411 automatic analyzer. The importance of the presentation is at p<0.05.
Results: From the results, it is seen that all the patients taking the study have found that there are significant changes in the hormones taken in the study (AMH and FSH) between the working group and the control group (p<0.00001). From the study, it has been found that women over the age of 35 have an increase in FSH (>20), while having an AMH (<0.5) decrease.
Discussion: Our results and other similar studies indicate that the AMH serum level of the AMH hormone shows ovarian storage and a valid and reliable test for infertility treatment. FSH as a hormonal predictor of infertility is significantly lower than the AMH hormone and the combination of AMH and FSH was not significantly better than the AMH.
Conclusion: From this original scientific paper it can be concluded that the determination of the concentration of these two hormones (AMH and FSH) is of great importance as regards the determination of female infertility over 35 yrs of age. From the results of this paper, we have also gained significant values for the decision-making of the healthcare professional as to which IVF/ICSI procedure. In most patients in whom the AMH<0.50 and FSH>20 hormone values have been determined, it is recommended by infertility health professionals to use hormone stimulating therapy because ovarian reserves are poor, so without the stimulation therapy the possibility that these females getting pregnant is too small or almost impossible. From this study we have observed in 6 cases that patients who had AMH>4.0 during the ultrasound examination we found that we have polycystic ovary syndrome (PCOS).