The main aim of this investigation is to develop fast disintegrating oral films of Propranolol hydrochloride by using Pectin and synthetic polymers. The Propranolol HCl oro-dispersible films were formulated by using HPMC E15LV, HPMC regular, pectin, Carbopol, and PVA, as film forming polymers. The selected polymers were natural and synthetic water soluble polymers. Generally solvent casting method was used in the manufacture of the mouth dissolving films. The formula which incorporates pectin HPMC E15 LV 4:2 and pectin: Carbopol 3:2 ratios and also other varying ratio were used in the formulation of Oro-dispersible films. The quantity and type of plasticizer affected the formulation of films; Propranolol HCl has bitter taste so taste masking agents were used. Citric acid was used as a salivary stimulating agent. The prepared films were subjected to the analysis of various evaluation tests such as weight variation, tensile strength, thickness, surface pH, and drug content. The significant parameters such as disintegration and dissolution profiles also studied in detail since the product was prepared for fast dissolving in the oral cavity.