Journal of Proteomics & Bioinformatics
Open Access

Abstract

Exploring Realm of Proteases of Leishmania donovani Genome and Gene Expression Analysis of Proteases under Apoptotic Condition.

Ritesh Kumar, Pratyajit Mohapatra and Vikash Kumar Dubey

Genomic analysis of Leishmania donovani has shed light on various proteases in the parasite genome, their classification and sub-cellular localization. Under apoptotic condition of the parasite, gene expression analyses of representative protease(s) from each clan shows altered expression levels of various proteases. The data indicates possible role of various proteases in apoptotic process, directly or indirectly. Over-expression of autophagy related protease genes under apparent apoptotic conditions show some crosstalk between autophagy and apoptosis like cell death of Leishmania parasite. The counter-regulation of these two processes in trypanosomatids in general and Leishmania in specific, needs further investigation.