Fungi are ubiquitous eukaryotic organisms, indispensably interlinked with other life-forms within our biosphere. We have been affected by this lifeform both positively and negatively. Efforts to nurture the benefits in the form of traditional knowledge have been done since time-immemorial. Technological advancements have ushered impetuses for the benefit of mankind. Amalgamation of microbial systems with Synthetic Biology has helped to reap the benefits for the betterment of mankind.