Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Thiago Martins Silva*
The opioid crisis has escalated into a global public health emergency, with Brazil witnessing a steady increase in opioid misuse and related fatalities. Amid this challenge, buprenorphine-naloxone combination therapy has emerged as a cornerstone pharmacological intervention for Opioid Use Disorder (OUD). The formulation combines buprenorphine, a partial opioid agonist, with naloxone, an opioid antagonist, to reduce misuse potential while maintaining therapeutic efficacy. This multi-center cohort study was conducted across five urban hospitals in Brazil and aimed to evaluate the effectiveness of buprenorphine-naloxone therapy in achieving sustained abstinence, improving treatment retention, and reducing relapse rates among individuals diagnosed with moderate to severe.
Published Date: 2025-03-04; Received Date: 2025-02-03