Endocrinology & Metabolic Syndrome
Open Access

Abstract

Estrogen Receptor Related Receptor Alpha (ERRα) in Skeletal Tissues

E. Bonnelye

Estrogen receptor related receptor alpha (ERRα) was the oldest orphan nuclear receptor with sequence identity to the estrogen receptors, ERα/β. The sequence alignment of the ERRα and the ERs reveals a high similarity (68%) in the DNA-binding domain and a moderate similarity (36%) in other parts of the proteins such as the ligand-binding E domain.