Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Enzyme Inhibition Strategies in the Management of Neurodegenerative Diseases: A Biochemical Perspective

Mariana Beatriz Santos*

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, represent a growing global health burden. These conditions are characterized by progressive neuronal loss, synaptic dysfunction, and eventual cognitive or motor decline. A critical biochemical hallmark of many neurodegenerative diseases is the dysregulation of enzymatic activity, often resulting in oxidative stress, protein misfolding, excitotoxicity, and impaired neurotransmitter metabolism. As such, targeting key enzymes through selective inhibition has emerged as a promising therapeutic strategy for slowing disease progression and alleviating symptoms.

Published Date: 2025-03-04; Received Date: 2025-02-03