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Context: We report two cases of acute kidney injury that developed after taking Dioscorea Quinqueloba for healthy diet. Dioscorea Quinqueloba is a medicinal herb that is widely used to treat cardiovascular disease and various medical conditions. Acute kidney injury associated with the use of herbal medicine is common throughout the world, but acute kidney injury cause by Dioscorea Quinqueloba has not been reported so far. Case details: 68-year-old man and his brother, who is 58-years-old, ingested the extract of Dioscorea Quinqueloba as traditional remedy. The following day, they complained symptoms of nausea, vomiting and diarrhea. Eventually, they were diagnosed with oliguric or non-oliguric acute renal failure, but improved without complications. Discussion: Dioscorea Quinqueloba should be correctly prepared for traditional medicine; otherwise it may cause a life-threatening acute kidney injury.