Background and objective: Ficus benghalensis is a remarkable tree that sends down its branches and great number of shoots. It is used for treatment of neuralgia, rheumatism, lumbago, bruises, nasitis, gonorrhoea, inflammations, cracks of the sole and skin diseases and in ayurveda for diarrhea, dysentery, and piles”. To evaluate protective activity of F. benghalensis latex extract (FBLE) on cisplatin induced hypotension and renal impairment in wistar rats. Materials and methods: Rats were divided five groups and duration study 16 days. 1st group administered 5 ml/kg normal saline; 2rd group FBLE treated group 400 mg/kg per day; 3rd group (cisplatin treated) with single dose of cisplatin (5 mg/kg, i.p.) on 1st day and keep animals up to 6 days; 4th Group and 5th Group FBLE treated (200 and 400 mg/kg, p.o.) of for 1st to 10th day and single dose of cisplatin (5 mg/kg, i.p.) on 11th day. Results: Phytochemical screening of FBLE has revealed presence of glycoside, alkaloids, tannin, flavonoids and amino acids, IC50 values for DPPH, and phosphor-molybdenum were 28.63 μg/ml ± 0.16 μg/ml, and 31.84 μg/ml ± 0.12 μg/ml respectively. The cisplatin-treated 3rd group showed a significant (**P<0.01) changes renal functions biochemical parameters, blood pressure and histopathology were significantly (**P<0.01) monitored by 200 mg/kg and 400 mg/kg protective groups. Conclusion: These findings demonstrated that the FBLE and their constituents have excellent nephroprotective and normalized blood pressure.