Drug Designing: Open Access
Open Access

Abstract

Dynamic Polypharmacology: Designing Single Molecules with Tunable Multi-Target Activity

Mei-Ling Tseng*

Dynamic polypharmacology represents a transformative approach in modern drug design, focusing on the development of single molecular entities capable of modulating multiple biological targets simultaneously. In contrast to the traditional one-drug- one-target paradigm, which has been the foundation of pharmacology for decades, polypharmacology acknowledges the complex, interconnected nature of disease pathways, especially in multifactorial disorders such as cancer, neurodegenerative diseases and metabolic syndromes. These diseases often involve multiple dysregulated signaling pathways and targeting a single node may not yield sufficient therapeutic efficacy. The dynamic aspect of polypharmacology introduces the concept of tenability, designing molecules that can adapt their affinity or selectivity depending on the local biological environment, thereby optimizing therapeutic outcomes and reducing unwanted side effects.

Published Date: 2025-03-04; Received Date: 2025-02-03